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KMID : 0061119830110000134
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Bulletin of the Clinical Research Institute
1983 Volume.11 No. 0 p.134 ~ p.134
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Suppression of Photocontact Hypersensitivity by Suberythemal doses of UVB Irradiation and Its Reversal by Low Dose of Cyclophosphamide
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Choi, Sung-Woo
chyung, Eun-Jung/Houh, Won
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Abstract
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Two groups of experimental animal were irradiated with supraerythernal doses of 45 mJ/㎠ and suberythemal doses of 15 mJ/㎠ of UVB respectively at the induction sites of photocontact sensitivity to musk ambrette as a pre-induction manipulation of UVB irradiation were additionally given 100 ㎎/㎏ cyclophosphamide i.p. injection.
This experiment reports 3 facts as follows:
1. UVB irradiation suppressed photocontact sensitivity reaction, : however more suppression was observed in the group received suberythema doses of 15 mJ/㎠ than the group received supraerythema doses of 45 mJicm2 (42.13% in 15 mJ/㎠ vs. 49.54% in 45 mJ/㎠).
2. The reversal of suppressed photocontact sensitivity reaction, by cyclophosphamide was observed. Even though both groups showed different levels of suppression depending upon the dosage of UVB irradiation, the magnitude of reversal by cyclophosphamide was not affected by the amount of suppression originally induced by UVB irradiation (53.70% in 15 mJ/㎠ vs. 53.24% in 45 mJ/㎠).
3. The reversal of suppressed photocontact sensitivity reaction was observed by the low dose of 100 ㎎/㎏ cyclophosphamide i.p. injection. This result would be conducive to determine the minimum effective dose of cyclophosphamide modulating contact sensitivity reaction.
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